Tsim Sha Tsui (English pronunciation: /ˌsɪm ˌʃɑː ˈsuː.iː/; Chinese: 尖沙咀; pinyin: Jiānshāzuǐ), often abbreviated as TST, is an urbanized area in southern Kowloon, Hong Kong. The area is administratively part of the Yau Tsim Mong District. Tsim Sha Tsui East is a piece of land reclaimed from the Hung Hom Bay now east of Tsim Sha Tsui. The area is bounded north by Austin Road and in the east by Hong Chong Road and Cheong Wan Road.

Geographically, Tsim Sha Tsui is a cape on the tip of the Kowloon Peninsula pointing towards Victoria Harbour, opposite Central. Several villages had been established in this location before Kowloon was ceded to the British Empire in 1860. Tsim Sha Tsui in Chinese means pointed sandy mouth. It was also known as Heung Po Tau (香埗頭), i.e. a port for exporting incense tree.

Tsim Sha Tsui is a major tourist hub in metropolitan Hong Kong, with many shops and restaurants that cater to tourists. Many of the museums in the territory are located in the area.

Historical maps in Ming or Qing Dynasty named the channel between Tsim Sha Tsui and Central as Chung Mun (Pinyin: Zhong Men, 中門, lit. the middle gate) as it is located in the middle of the two other channels, Kap Shui Mun in the west and Lei Yue Mun in the east, in the harbour.

Before Kowloon was ceded to Britain in 1860, many villages were present in the area. Incense trees (Aquilaria sinensis) from New Territories were gathered at some quays in Tsim Sha Tsui and transferred to Shek Pai Wan in southern Hong Kong Island to be exported to rest of the world. It was thus known as Heung Po Tau, the fragrant quay.

In 1888, the Star Ferry offered regular transport between Central and Tsim Sha Tsui, and the area has flourished ever since. The place has an international reputation for the large number of tiger sharks resident in the waters close by. Tsim Sha Tsui was a garden city exclusive for westerners in that era. In the early 20th century, Chinese people were allowed to live in the area in order to attract more people to trade in the colony. Garden houses were replaced with crowded residential blocks. Wharves and godowns were built along the west shore. Major developers like Hormusjee Naorojee Mody and Catchick Paul Chater actively participated in the development of Tsim Sha Tsui.

The Kowloon-Canton Railway (British Section) commenced service on 1 October 1910. Kowloon Station in Tsim Sha Tsui was built on the new southern reclamation from 1913 to 1915. The rails extended along the western reclamation parallel to Chatham Road, with old Hung Hom Station near the Gun Club Hill Barracks at the junction of Chatham Road and Austin Road. Another major road, Salisbury Road, was completed in approximately the same period. The landmark Peninsula Hotel was built on the reclamation in 1928, opposite to the station.

The Kowloon Station was relocated to a new Hung Hom Station in 1978. The whole station and rails were demolished except the landmark Clock Tower. Hong Kong Space Museum and later the Hong Kong Cultural Centre were erected on the site. The rails were replaced with New World Centre and other gardens in Tsim Sha Tsui East.

Before any land reclamation, Tsim Sha Tsui consisted of two parallel capes with a bay in between in the south. The west cape, Kowloon Point, the proper Tsim Sha Tsui, coincided with the small hill where the Former Marine Police Headquarters Compound is sited, while the east cape was the hill that is today known as Blackhead Point. The bay between the capes extended as far north as the present-day Mody Road. Today, Canton Road marks the western edge of Tsim Sha Tsui, and Chatham Road the eastern edge. The area is hilly, although many hills were leveled for reclamation.